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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
22.42
Human Site:
S245
Identified Species:
35.24
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S245
I
T
F
Q
P
D
L
S
K
F
K
M
E
K
L
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S253
I
T
F
Q
P
D
L
S
K
F
K
M
E
K
L
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S239
I
T
F
Q
P
D
L
S
K
F
K
M
E
K
L
Dog
Lupus familis
XP_534241
2041
231068
S663
I
T
F
Q
P
D
L
S
K
F
K
M
E
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S233
I
T
F
Q
P
D
L
S
K
F
K
M
E
K
L
Rat
Rattus norvegicus
P41516
1526
173202
I233
M
Q
S
L
D
K
D
I
V
A
L
M
V
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
A548
I
T
F
Q
P
D
L
A
K
F
K
M
D
K
L
Chicken
Gallus gallus
O42131
1627
183228
S250
I
T
F
Q
P
D
L
S
K
F
K
M
E
N
L
Frog
Xenopus laevis
NP_001082502
1579
178601
I233
M
Q
I
L
D
K
D
I
V
A
L
M
S
R
R
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
A244
V
T
F
Q
P
D
L
A
K
F
N
M
E
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
I187
G
K
A
S
D
V
Q
I
K
D
F
N
G
T
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
A259
I
T
F
S
P
D
L
A
K
F
K
M
K
E
L
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
N188
K
K
V
T
G
G
R
N
G
Y
G
A
K
L
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
E213
I
T
K
C
N
K
S
E
N
W
T
K
V
T
F
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K168
A
D
L
N
V
G
Q
K
Y
V
Q
K
W
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
86.6
93.3
6.6
80
N.A.
6.6
N.A.
73.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
93.3
20
93.3
N.A.
6.6
N.A.
93.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
0
0
20
0
14
0
7
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
7
0
0
20
60
14
0
0
7
0
0
7
0
7
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
0
0
47
14
0
% E
% Phe:
0
0
60
0
0
0
0
0
0
60
7
0
0
0
7
% F
% Gly:
7
0
0
0
7
14
0
0
7
0
7
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
60
0
7
0
0
0
0
20
0
0
0
0
0
0
0
% I
% Lys:
7
14
7
0
0
20
0
7
67
0
54
14
14
47
0
% K
% Leu:
0
0
7
14
0
0
60
0
0
0
14
0
0
7
60
% L
% Met:
14
0
0
0
0
0
0
0
0
0
0
74
0
0
0
% M
% Asn:
0
0
0
7
7
0
0
7
7
0
7
7
0
7
7
% N
% Pro:
0
0
0
0
60
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
14
0
54
0
0
14
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
0
0
0
14
14
% R
% Ser:
0
0
7
14
0
0
7
40
0
0
0
0
7
0
0
% S
% Thr:
0
67
0
7
0
0
0
0
0
0
7
0
0
14
0
% T
% Val:
7
0
7
0
7
7
0
0
14
7
0
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _